@article{bibcite_6206,
  author = {Ana Kojic and Javid Moslehi and Bonnie Ky and Joseph C. Wu},
  title = {Cardiometabolic disease and cardio-oncology: Insights from iPSC models and tissue engineering},
  abstract = {Heart disease and cancer share common risk factors, genetic predispositions, and metabolic and inflammatory components. Metabolic reprogramming can drive disease progression in both, with cardiometabolic syndrome{\textemdash}marked by obesity, insulin resistance, dyslipidemia, and hypertension{\textemdash}contributing to cancer development. Studies link around 20\% of cancer cases to obesity, while elevated glucose and triglyceride levels increase the risk of liver, thyroid, and respiratory cancers. Beyond treatment-related cardiotoxicity, cancer patients often have pre-existing cardiovascular disease (CVD) at diagnosis, highlighting their bidirectional relationship. Patient-specific induced pluripotent stem cells (iPSCs) offer a powerful platform to study these links at a personalized level. iPSC models help explore shared molecular mechanisms, metabolic dysregulation, inflammation, and cardiotoxicity. This review examines emerging themes in cardio-oncology and cardio-metabolism, emphasizing how iPSC-based approaches can reveal disease connections and inform new therapies.},
  year = {2025},
  journal = {Cell Reports Medicine},
  volume = {6},
  pages = {102261},
  month = {2025-09-16},
  issn = {2666-3791},
  url = {https://www.sciencedirect.com/science/article/pii/S2666379125003349},
  doi = {10.1016/j.xcrm.2025.102261},
}