@article{5766, keywords = {Cancer-associated fibroblasts, Esophageal adenocarcinoma, organ-on-a-chip, organoids}, author = {Sanjima Pal and Elee Shimshoni and Salvador Flores Torres and Mingyang Kong and Kulsum Tai and Veena Sangwan and Nicholas Bertos and Swneke Donovan Bailey and Julie Bérubé and Donald E. Ingber and Lorenzo Ferri}, title = {Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology}, abstract = {Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide, with increasing incidence in North America. As no targeted therapy or immunotherapy has revolutionized the management of EAC, chemotherapy is the only standard of care. Most patients with EAC experience poor outcomes because of the inherent or acquired resistance to chemotherapy.}, year = {2025}, journal = {Journal of Translational Medicine}, volume = {23}, pages = {577}, month = {2025-05-23}, issn = {1479-5876}, url = {https://doi.org/10.1186/s12967-025-06593-1}, doi = {10.1186/s12967-025-06593-1}, }