@article{5721,
  author = {Fahimeh Shahabipour and Sandro Satta and Mahboobeh Mahmoodi and Argus Sun and Natan Roberto de Barros and Song Li and Tzung Hsiai and Nureddin Ashammakhi},
  title = {Engineering organ-on-a-chip systems to model viral infections},
  abstract = {Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to investigate therapeutics targeting the COVID-19 spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and three-dimensional (3D) microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of the in vitro OoC-based modeling of viral infection, highlighting the strengths and challenges for the future.},
  year = {2023},
  journal = {Biofabrication},
  volume = {15},
  pages = {022001},
  month = {2023-02},
  issn = {1758-5090},
  url = {https://dx.doi.org/10.1088/1758-5090/ac6538},
  doi = {10.1088/1758-5090/ac6538},
  language = {en},
}