@article{5716,
  keywords = {Antiviral drugs, Gut-on-a-chip, Human organs-on-a-chip, Influenza, Liver-on-a-Chip, lung-on-a-chip, Lymph nodes-on-a-chip, SARS-CoV-2, vaccine, Virology},
  author = {Jing Li and Haiqing Bai and Zihao Wang and Beibei Xu and Kristen N. Peters Olson and Chengyao Liu and Yinlei Su and Jiawei Hao and Jinying Shen and Xuetong Xi and Jie Zhen and Rong Yu and Yacong Sun and Xin Xie and Wen-xia Tian and Fei Yu and Xiaoheng Liu and Lihe Zhang and Demin Zhou and Longlong Si},
  title = {Advancements in organs-on-chips technology for viral disease and anti-viral research},
  abstract = {Disease models that can accurately recapitulate human pathophysiology during infection and clinical response to antiviral therapeutics are still lacking, which represents a major barrier in drug development. The emergence of human Organs-on-a-Chip that integrated microfluidics with three-dimensional (3D) cell culture, may become the potential solution for this urgent need. Human Organs-on-a-Chip aims to recapitulate human pathophysiology by incorporating tissue-relevant cell types and their microenvironment, such as dynamic fluid flow, mechanical cues, tissue–tissue interfaces, and immune cells to increase the predictive validity of in vitro experimental models. Human Organs-on-a-Chip has a broad range of potential applications in basic biomedical research, preclinical drug development, and personalized medicine. This review focuses on its use in the fields of virology and infectious diseases. We reviewed various types of human Organs-on-a-Chip-based viral infection models and their application in studying viral life cycle, pathogenesis, virus-host interaction, and drug responses to virus- and host-targeted therapies. We conclude by proposing challenges and future research avenues for leveraging this promising technology to prepare for future pandemics.},
  year = {2023},
  journal = {Organs-on-a-Chip},
  volume = {5},
  pages = {100030},
  month = {2023-12-01},
  issn = {2666-1020},
  url = {https://www.sciencedirect.com/science/article/pii/S2666102023000058},
  doi = {10.1016/j.ooc.2023.100030},
}