@article{bibcite_4066,
  keywords = {CAR-T cells, Cancer, cancer immunotherapy, cancer model, organ-on-chip, solid tumor, tumor immunology, Tumor Microenvironment},
  author = {Tengku Ibrahim Maulana and Claudia Teufel and Madalena Cipriano and Julia Roosz and Lisa Lazarevski and Francijna E. van den Hil and Lukas Scheller and Valeria Orlova and Andr{\'e} Koch and Michael Hudecek and Miriam Alb and Peter Loskill},
  title = {Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells},
  abstract = {Physiologically relevant human models that recapitulate the challenges of solid tumors and the tumor microenvironment (TME) are highly desired in the chimeric antigen receptor (CAR)-T cell field. We developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture over a period of up to 8~days. Here, we exemplified its use for investigating CAR-T cell efficacy and the ability to control the immune reaction with a pharmacological on/off switch. Additionally, we integrated primary breast cancer organoids to study patient-specific CAR-T cell efficacy. The modular architecture of our tumor-on-chip paves the way for studying the role of other cell types in the TME and thus provides the potential for broad application in bench-to-bedside translation as well as acceleration of the preclinical development of CAR-T cell products.},
  year = {2024},
  journal = {Cell Stem Cell},
  volume = {31},
  pages = {989-1002.e9},
  month = {2024-07-05},
  issn = {1934-5909},
  url = {https://www.sciencedirect.com/science/article/pii/S1934590924001450},
  doi = {10.1016/j.stem.2024.04.018},
}