@article{bibcite_3806,
  keywords = {Biomedical Engineering, Organogenesis, Skin models},
  author = {Hasan Erbil Abaci and Abigail Coffman and Yanne Doucet and James Chen and Joanna Jack{\'o}w and Etienne Wang and Zongyou Guo and Jung U. Shin and Colin A. Jahoda and Angela M. Christiano},
  title = {Tissue engineering of human hair follicles using a biomimetic developmental approach},
  abstract = {Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed molds. Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs. Furthermore, vascularization of hair-bearing HSCs prior to engraftment allows for efficient human hair growth in immunodeficient mice. The ability to regenerate an entire HF from cultured human cells will have a transformative impact on the medical management of different types of alopecia, as well as chronic wounds, which represent major unmet medical needs.},
  year = {2018},
  journal = {Nature Communications},
  volume = {9},
  pages = {5301},
  month = {2018-12-13},
  issn = {2041-1723},
  url = {https://www.nature.com/articles/s41467-018-07579-y},
  doi = {10.1038/s41467-018-07579-y},
  language = {en},
}